Just saw my first patient on Xarelto. Not aware of any guidelines on how long to hold prior to ESI and when it can be restarted. Any thoughts on this? Thanks!
An epidural catheter should not be removed earlier than 18 hours after the last administration of XARELTO®. The next XARELTO® dose is not to be administered earlier than 6 hours after the removal of the catheter. Delay the administration of XARELTO® for 24 hours if traumatic puncture occurs
The information above is from the package insert. Also, it is contraindicated in renal impairment (creatinine clearance < 15 mL/min), moderate and severe hepatic impairment with elevated INR.
I recommend to my patients to hold for 24 hours.
Why only 24 hours? It seems like it would take more than 24 hours for the body to completely replace the Factor Xa, (and that's once the drug has left the body).
It seems that a few years after every new blood thinner is introduced, the required time to hold it for neuroaxial procedures is increased, (after unexpected bleeds are reported).
I'd rather skip that possibility in my patient needing a cervical ESI.
Due to it's pharmacokinetics, and PI, I treat it as other Xa inhibitors such as LMWH and follow the ARSA Guidelines for therapeutic doses -> hold for 24 hours.
It depends on when surgery is scheduled. It's supposed to be taken with the heaviest meal of the day (typically dinner), so it could be closer to 30+ hours if you take it with dinner Wednesday night and surgery is Friday morning.So nobody has an opinion on this besides NOSFAN?
No one ever sees patients on Xarelto besides me?
Has anyone heard of using for surgeries other than knee/hip replacement? Just curious of outcomes/types of surgery where experience is being gained (no locations, just patient type/outcomes).Due to it's pharmacokinetics, and PI, I treat it as other Xa inhibitors such as LMWH and follow the ARSA Guidelines for therapeutic doses -> hold for 24 hours.
Thought I'd bump this thread since I just saw my first referral on Xarelto. Some of the stories I've seen from surgeons are horrifying.
Anything new?
All of the above.
One surgeon said it helped him make an early dx of rectal CA because the pt started bleeding.
Why only 24 hours? It seems like it would take more than 24 hours for the body to completely replace the Factor Xa, (and that's once the drug has left the body).
It seems that a few years after every new blood thinner is introduced, the required time to hold it for neuroaxial procedures is increased, (after unexpected bleeds are reported).
I'd rather skip that possibility in my patient needing a cervical ESI.
48 hours is what the cardiologist say for eliquis
Cardiologist always underestimate these things, because their priority is different from ours. 10 years ago they would say you only need to hold plavix for 3 days, lovenox for 10 hrs, etc.
I always at least double whatever time period the cardiologist thinks
we had a patient who ws on ASA 81 and Xarelto- both held for 5 d for cervical MBB procedure and she had a fair amount of bleeding noted subcutaneously after first injection. The rest of procedure aborted, I would rather be conservative and these are elective procedures.... however 5 days shoulder be plenty. Granted MBB is not neuroaxial its still close enough. Cards is giving push back to hold for longer.. she is in a fib. also I am not too excited about wanting to proceed w this one.
How long would you hold it for...
Would not hold anticoag for MBB or SIJ. Not in the neuraxis. Skin bleeding is not predictive of internal bleeding.[/quote
It was not skin bleeding topically, more of subcutaneous pooling in a 2 inch area . Notable bruising on post procedure followup as well.
Would not hold anticoag for MBB or SIJ. Not in the neuraxis. Skin bleeding is not predictive of internal bleeding.