I looked over the pre-requisites to be sure I wouldn't need an extra class for any particular school. Then I perused the school's web sites, learning everything I could about their philosophy, method of teaching, research interests, amount of clinical exposure, etc. I also looked at the percentage of out of state applicants who were accepted, and how I compared to their average student with GRE scores and GPA. I compiled a list of 12 schools I was highly interested in and then sat down with my husband to narrow it down.
We ended up choosing 8 of the schools based on whether or not he would be likely to find employment in his field within commuting distance. I applied to Knoxville (my state school), Auburn, CSU, Penn, Iowa State, Illinois, Wisconsin, and Purdue. I was rejected by Purdue, Penn, Auburn, Wisconsin and CSU. I interviewed with Illinois and Knoxville. I was selected as an alternate at Iowa State and Illinois and offered admission at Knoxville.
In the end, I could have saved a lot of time and money applying only to Knoxville, but I think I would have been happy at any of those schools.