glycogen storage diseases

  1. B

    Why hepatomegaly in Von Gierke?

    I understand how G6P being trapped leads to the other symptoms via pathway shunting, but why is there increased glycogen? Does G6P feedback to inhibit glycogenolysis? I don't think it'd be possible to shunt the G6P to glycogen synthesis since the hypoglycemia would lead to hormonal inhibition of...