1qwk oral morphine OCD?

[cbrons]

Anyone ever heard of or know any other investigations with mu-agonist/glutamine antagonists in the treatment of OCD?

http://www.ncbi.nlm.nih.gov/pubmed/15766302

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[nitemagi]

Nope.

 

[cbrons]

Nope.

I e-mailed Dr. Koran to see if she knows of any other investigations on-going. I will share the info if and when she does respond.

 

[whopper]

There is a theory I hear mentioned here and there but I cannot find validation of it in journals that u-receptor stimulation causes release of serotonin and dopamine. I have seen a guy put on Suboxone become manic, seemingly as a result of the Suboxone. It was either that or this guy just happened to have a manic episode start a few days after the Suboxone started.

How valid is the theory? Don't know. Several people abuse opioids to relieve anxiety. It could be that the euphoria caused by the opioids really isn't therapeutically doing something other than making the person more euphoric, thus improving their ability to tolerate obsessions.

 

[cbrons]

There is a theory I hear mentioned here and there but I cannot find validation of it in journals that u-receptor stimulation causes release of serotonin and dopamine. I have seen a guy put on Suboxone become manic, seemingly as a result of the Suboxone. It was either that or this guy just happened to have a manic episode start a few days after the Suboxone started.

How valid is the theory? Don't know. Several people abuse opioids to relieve anxiety. It could be that the euphoria caused by the opioids really isn't therapeutically doing something other than making the person more euphoric, thus improving their ability to tolerate obsessions.

Have you heard anything about glutamate-targeted treatments for OCD? I.e. with Riluzole?

 

[nitemagi]

I'm guessing someone on this thread has to do a presentation for their rounds, on alternative tx's for OCD.

 

[cbrons]

Have you heard anything about glutamate-targeted treatments for OCD? I.e. with Riluzole?

I'm guessing someone on this thread has to do a presentation for their rounds, on alternative tx's for OCD.

No sir, this is purely out of my own interests.

Here is a link for the Riluzole tx:

http://www.biologicalpsychiatryjournal.com/article/S0006-3223(05)00563-9/abstract

 

[nitemagi]

Anti-glutamatergic agents are being investigated for a host of disorders and are hotly discussed as treatments for everything from psychosis to mood disorders. It's all investigational, though. You'd be going way off-label to be trying riluzole, and that stuff ain't cheap.

 

[cbrons]

Anti-glutamatergic agents are being investigated for a host of disorders and are hotly discussed as treatments for everything from psychosis to mood disorders. It's all investigational, though. You'd be going way off-label to be trying riluzole, and that stuff ain't cheap.

Dr. Koran from Standford University (the one who conducted the original research cited in the OP) got back to me. She sent me a few articles (which I attached) on glutamate-targeted research/treatment.

 

[psychphan]

How valid is the theory? Don't know. Several people abuse opioids to relieve anxiety. It could be that the euphoria caused by the opioids really isn't therapeutically doing something other than making the person more euphoric, thus improving their ability to tolerate obsessions.

That likely has a lot to do with the abuse of opiods, however, in this study the qweek dosing would suggest that some other mechanism is in effect as well, as the euphoria would have worn off for a significant time in between doses, and one would even expect some rebound dysphoria during that time I would think.

 

[ghost dog]

There is a theory I hear mentioned here and there but I cannot find validation of it in journals that u-receptor stimulation causes release of serotonin and dopamine. I have seen a guy put on Suboxone become manic, seemingly as a result of the Suboxone. It was either that or this guy just happened to have a manic episode start a few days after the Suboxone started.

How valid is the theory? Don't know. Several people abuse opioids to relieve anxiety. It could be that the euphoria caused by the opioids really isn't therapeutically doing something other than making the person more euphoric, thus improving their ability to tolerate obsessions.

This is why a psych Dx is a risk factor for aberrant opioid behavior as per the opioid risk tool.

 

[cbrons]

This is why a psych Dx is a risk factor for aberrant opioid behavior as per the opioid risk tool.

Are patients with OCD usually the type to abuse drugs? I figure many of them are paranoid about taking them in the first place.