Quantcast

A little help w/ hermaphroditism...

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

StringBean

Senior Member
5+ Year Member
15+ Year Member
Joined
Apr 6, 2004
Messages
266
Reaction score
4

Members don't see this ad.
So I'm not seeing a clear distinction between male pseudohermaphroditism and testicular feminization syndrome. Both are 46 XY, both are 'normal' appearing females w/ female genitalia and both have testes present. I know the mechanisms behind them are different (androgen insensitivity vs defective DHT receptor) but is there any other difference that I'm just not seeing? Do they present the same & can you distinguish them clinically?

Thanks!
2 days, 8 hours & counting!
 

jakstat33

Senior Member
10+ Year Member
15+ Year Member
Joined
Feb 6, 2004
Messages
265
Reaction score
0
hey- i expect ?'s about these 2 malformations to involve a basic understanding of the cause (male PH: no MIF/tes vs. AIS: as you said, defective receptor)... ummm, i also remember that with ais patients have a blind ending vagina, i am not sure if you see this with male pseudo (ambiguous genitalia).

then again, what do i know? i'll tell you if this shows up on my test Wed night, g'luck :thumbup:

StringBean said:
So I'm not seeing a clear distinction between male pseudohermaphroditism and testicular feminization syndrome. Both are 46 XY, both are 'normal' appearing females w/ female genitalia and both have testes present. I know the mechanisms behind them are different (androgen insensitivity vs defective DHT receptor) but is there any other difference that I'm just not seeing? Do they present the same & can you distinguish them clinically?

Thanks!
2 days, 8 hours & counting!
 

barone ROCKS

Member
10+ Year Member
5+ Year Member
Joined
Jun 19, 2004
Messages
54
Reaction score
0
look at it this way

if ur 46xy pseudoherm, you dont have mif so both female and male internal genitalia develop. the key here is that you still have testicles...and no ovarian tissue which seperates this from true herms

in receptor insensitivity you dont get female internal genitalia since mif is present and you dont get male internal genitalia due to receptor insensitivity. you do get female external genitalia ...2/3 vagina ending in a blind pouch.

my usual disclaimer...this is all from memory so if someone could confirm or correct my explaination...ty
 

Idiopathic

Newly Minted
Lifetime Donor
15+ Year Member
Joined
Apr 21, 2003
Messages
8,362
Reaction score
18
Male pseudohermaphroditism includes both androgen receptor deficiency/testicular feminization and 5-a-reductase deficiency (no DHT).

I think one huge difference is that LH will be off the charts in the first case, and not so in the second case.
 
Top