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I receive this in an email from a med school. It is a homework assignment that is to be handed in on the first day of class. For all of you that want to get a head start or want to freak out early, here goes:
[FONT=Arial,Arial]1. Review organic chemistry nomenclature and structure (hexose, pentose, aldehyde, alcohol, amino group, amide, carboxylic acid, ketone, enol, anhydride, ester, sulfhydryl, disulfide, phosphate group, organic phosphate, orthophosphate). Draw an example of each.
2. Review pH, including calculations of pKa and pH from the Henderson-Hasselbalch equation. Write the Henderson-Hasselbalch equation.
3. Review the four major classes of macromolecules found in the body (proteins, carbohydrates, lipids, nucleic acids) and their structures and major roles. Name two examples of each of the four types.
4. Be able to name all twenty common amino acids from their structures. List the names and three letter abbreviations for the twenty amino acids.
5. List the functions (i.e. what are the starting and ending materials, and what is the purpose of the pathway?) of the major metabolic pathways (glycolysis, gluconeogenesis, glycogen synthesis, glycogenolysis, pentose phosphate pathway, tricarboxylic acid cycle, electron transport, oxidative phosphorylation, fatty acid synthesis, beta-oxidation, triglyceride synthesis, cholesterol synthesis, ketone synthesis, purine and pyrimidine synthesis and degradation.) Name two enzymes that catalyze reactions in each of the pathways.
6. Name any five enzymes that are targets for pharmacological intervention together with the relevant pharmaceutical and the disease or symptom to be treated (e.g. Lipitor targets hydroxymethylglutarylCoA reductase to inhibit endogenous cholesterol synthesis).
These answers are to be handed in on the first day of class. Please do not feel a false sense of security because all of the above are first order (name, list, etc.) types of questions. We begin slowly, but step it up rapidly.
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Good luck and happy hunting!
.
1st year Class
This material can be found by using a good biology text, a biochemistry text, or, if you do not have either, by using a search engine. [FONT=Arial,Arial]1. Review organic chemistry nomenclature and structure (hexose, pentose, aldehyde, alcohol, amino group, amide, carboxylic acid, ketone, enol, anhydride, ester, sulfhydryl, disulfide, phosphate group, organic phosphate, orthophosphate). Draw an example of each.
2. Review pH, including calculations of pKa and pH from the Henderson-Hasselbalch equation. Write the Henderson-Hasselbalch equation.
3. Review the four major classes of macromolecules found in the body (proteins, carbohydrates, lipids, nucleic acids) and their structures and major roles. Name two examples of each of the four types.
4. Be able to name all twenty common amino acids from their structures. List the names and three letter abbreviations for the twenty amino acids.
5. List the functions (i.e. what are the starting and ending materials, and what is the purpose of the pathway?) of the major metabolic pathways (glycolysis, gluconeogenesis, glycogen synthesis, glycogenolysis, pentose phosphate pathway, tricarboxylic acid cycle, electron transport, oxidative phosphorylation, fatty acid synthesis, beta-oxidation, triglyceride synthesis, cholesterol synthesis, ketone synthesis, purine and pyrimidine synthesis and degradation.) Name two enzymes that catalyze reactions in each of the pathways.
6. Name any five enzymes that are targets for pharmacological intervention together with the relevant pharmaceutical and the disease or symptom to be treated (e.g. Lipitor targets hydroxymethylglutarylCoA reductase to inhibit endogenous cholesterol synthesis).
These answers are to be handed in on the first day of class. Please do not feel a false sense of security because all of the above are first order (name, list, etc.) types of questions. We begin slowly, but step it up rapidly.
*
Good luck and happy hunting!
.