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At the recent "Annual Scientific Assembly of the American College of Chest Physicians" held in Montreal this October, new studies have revealed that swabs of a patient's buccal mucosal cells may help diagnose lung cancer with an accuracy of 50%. There is a significant association between global DNA
methylation in buccal mucosal cells and malignant tissues of the lung (certain methylation patterns of DNA can lead to expression of oncogenes).
"The human lung is inaccessible for direct examination. Buccal cells lining the inner cheek of tobacco smokers are carcinogen- and oxidant-exposed, easily accessible, and potentially valuable surrogates for lung tissue. Lung cancer susceptibility phenotyping might include carcinogen-metabolism and oxidant-metabolism gene expression assayed in buccal cells."
I wouldn't be surprised if dentists get more involved in chairside diagnostic procedures for other illnesses in the future (ie.more oral medicine/oral pathology). As we begin to observe a trend of more and more patients with caries-free mouths, dentists will have to find other procedures to do in the oral cavity.
Comments?
methylation in buccal mucosal cells and malignant tissues of the lung (certain methylation patterns of DNA can lead to expression of oncogenes).
"The human lung is inaccessible for direct examination. Buccal cells lining the inner cheek of tobacco smokers are carcinogen- and oxidant-exposed, easily accessible, and potentially valuable surrogates for lung tissue. Lung cancer susceptibility phenotyping might include carcinogen-metabolism and oxidant-metabolism gene expression assayed in buccal cells."
I wouldn't be surprised if dentists get more involved in chairside diagnostic procedures for other illnesses in the future (ie.more oral medicine/oral pathology). As we begin to observe a trend of more and more patients with caries-free mouths, dentists will have to find other procedures to do in the oral cavity.
Comments?