As erg pointed out, based on just about everything I've heard, academic medicine tends to entail longer hours and more RVU-related pressures than would a typical VA position. The flip side is that there are plenty of opportunities for novel, collaborative, multi-disciplinary research. And there's likely to be more flexibility when it comes to a variety of contractual factors, such as negotiating salary, start-up funds/hiring bonus, and setting up the potential for clinical time buy-out with grant funds; VA positions with a true clinical/research split (i.e., where you're actually compensated for both) are relatively rare.
I explicitly discuss the VA given that I'd imagine it's one of the primary alternatives folks consider when looking at AMC spots.