Acute HBV and Anti-HBe

Discussion in 'Step I' started by dyspareunia, May 13, 2014.

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  1. dyspareunia

    dyspareunia

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    Is it technically correct to say that Anti-HBeAg is detectable during acute HBV? The graph in FA (pg 166 FA14) and also Pathoma show Anti-HBeAg levels beginning at around the 5th month post-exposure and peaking during the window period.

    Edit: Robbin's actually shows Anti-HBe peaking even earlier at ~12-24 weeks.
     
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  3. Ionian

    Ionian 2+ Year Member

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    Yes, Anti-HBeAg can occur during the acute phase, window phase, and the chronic phase.

    That's why we only use it to define early recovery ('window period') when only Anti-HBe, and Anti-HBc (Igm) occur, in the absence of antigen.
    But, you would know this is a recovery phase anyway, simply from the lack of antigen.

    Just basic rules.
    (IgM) antibodies and antigen = Acute HBV
    (IgG) antibodies and antigen = Chronic HBV
    Antibodies only = Recovery
    Presence of HBe antigen = 'high infectivity'

    I think specifically trying to define when/where/how Anti-E occurs is irrelevant.
     
    Last edited: May 13, 2014
    CherryRedDracul and dyspareunia like this.

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