Adjuvant RT for uterine Ca with bilateral ovarian mets and positive peritoneal cyto!

[Kroll2013]

Dear colleagues, is there an indication for adjuvant RT (after completion of adjuvant chemo) in a 45 yo pt , that has an endometrioid ADCa of the uterus , invading more than one third of the endometrium with bilateral mets to the ovaries and positive peritoneal cytology? No positive LNs.


Thx

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[xrthopeful]

What about the Secord Data? PMID 17688923 though that's retrospective

There's prospective phase II data as well - http://www.ncbi.nlm.nih.gov/pubmed/21239048

 

[Palex80]

Do it! 45 Gy for the whole pelvis incl. nodes, boost primary tumor sites to 54 Gy.

 

[seper]

I would not boost but 45 Gy after chemo has a good chance of helping her.

 

[Reaganite]

Would treat whole pelvis to 45 Gy as well. I've seen a couple of nasty, symptomatic posterior cul-de-sac implants in patients with initial ovarian involvement and positive cytology who didn't get consolidative RT after chemo.

 

[Pewl]

Would definitely treat WP 45Gy.