ADPKD Renin Production

Discussion in 'Step I' started by Sublimazing, May 17, 2014.

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  1. Sublimazing

    Sublimazing 5+ Year Member

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    Feb 19, 2012
    the shreve
    Dentist
    Physician
    ADPKD presents with hypertension 2/2 to renin production but is that renin produced due to:

    1. Increased amount of JG cells producing renin?

    or

    2. Some sort of obstruction leading to JG perceiving a low volume state and having a physiologic response?

    or

    3. ?

    Thanks....Step 1 in 3 days...argghh.
     
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  3. tantacles

    tantacles Lifetime Donor SDN Moderator 7+ Year Member

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    Physician
    My interpretation has always been that the cysts are obstructive, which thus leads to more firing of JG cells. So #2.
     
  4. Enzymes

    Enzymes 2+ Year Member

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    Mar 13, 2012
    I agree with the obstructive explanation, actually. Seems like cysts in the cortex and medulla are just going to decrease parenchymal cells.
     
    Last edited: May 17, 2014

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