Adrenal gland hormones, the hek?

[Caribeari]

Quick question: my patho book says that glucocorticoids are synthesized in the zona fasciculata and the zona reticularis of the adrenal cortex. I have always thought it was only in the zona fasciculata and I cannot find any other sources saying the zona reticularis also produces glucocorticoids. Does my patho book have an error or am I just not finding the info elsewhere to confirm? I don't want to be remembering the wrong info. >.<

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[delamj]

Your path book is correct. Corticosterone, the aldosterone precursor produced in the reticularis, has both weak glucocorticoid and mineralocorticoid effects; once it becomes aldosterone the mineralcorticoid effects predominate.


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[Caribeari]

Thank you!

 

[stickgirl390]

Isn’t corticosterone produced in the zona glomerulosa, not reticularis?

 

[Caribeari]

Isn’t corticosterone produced in the zona glomerulosa, not reticularis?

Taken directly from my patho book: "The glucocorticoid hormones, mainly cortisol, are synthesized in the zona fasciculata and the zona reticularis of the adrenal cortex." My First Aid book says it's produced in the zona fasciculata. I also found this: Corticosterone - an overview | ScienceDirect Topics, which also says zona fasciculata and further explains the conversion into aldosterone in the zona glomerulosa. I can't find anything that says it's synthesized in the zona glomerulosa, just that it's converted there. But at least this answered a large chunk of my question!

 

[Caribeari]

I find it kind of sad that my patho book doesn't even explain the conversion though. I need a better patho book methinks. This is the one that came with my program.

 

[stickgirl390]

First aid = best aid

 

[Deecee2DO]

its not so cut and dry. Theyll never ask you that kind of detail at least i know for Step 1. In real life there arent hard cutoffs really just highest concentrations of respective hormones follow the general rule Salt Sugar Sex GFR respectively

 

[Matthew9Thirtyfive]

Taken directly from my patho book: "The glucocorticoid hormones, mainly cortisol, are synthesized in the zona fasciculata and the zona reticularis of the adrenal cortex." My First Aid book says it's produced in the zona fasciculata. I also found this: Corticosterone - an overview | ScienceDirect Topics, which also says zona fasciculata and further explains the conversion into aldosterone in the zona glomerulosa. I can't find anything that says it's synthesized in the zona glomerulosa, just that it's converted there. But at least this answered a large chunk of my question!

That’s what zanki says too. That’s good enough for me.