Alkylating Agents

[TerpMD]

FA says they are cell cycle nonspecific but UW says they are S phase specific. Any thoughts? Thanks!

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[Lany]

alk. agents bind to the ds dna (cross-linkage) and disrupt dna synthesis and/or rna transcription. The incorporation of these agents occur during the s-phase yet they can still enter G2 phase (hence non-specific) and mitosis for some but cant complete replication. In case of bleomycin, i would assume that the alkyl agent incorporated prevents it from even going into the mitosis stage. Since it stops replication at G2 phase, its under cell-cycle specific, yet also under cell-cycle non-specific since it started (incorporation) at S phase. I hope step1 is not that picky.

lol.. i jus realized i havent figured out which one to pick either.. hmm.. it would still be a guess but i would go with non-specific. (except for bleomycin even though it could screw me over cause working at G2 and also inducing free radical that break the strand)

 

[TerpMD]

Yeah, I think I will just stick to FA. UW also said that antimetabolites were G1 specific when I thought they were S specific so who knows what is up with the UW cell cycle pic!