Allopurinol and 6-MP, FA 2014 error?

[mybubbles627]

FA 2014 on page 441 says to INCREASE 6-MP dose if taken with allopurinol. Shouldn't this say DECREASE 6-MP dose? Am I misinterpreting what it is saying?

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[haloschief]

Inhibits xanthine oxidase,  conversion of xanthine to uric acid. Also used in lymphoma and leukemia to prevent tumor lysis–associated urate nephropathy. Increased concentrations of azathioprine and 6-MP (both normally metabolized by xanthine oxidase).

It doesn't say that. Says you get increased concentration of 6-MP and azathioprine with allopurinol.

Also check here for errata: http://www.firstaidteam.com/proposed-step-1-errata-view-2

 

[periaqueductal]

FA 2014 on page 441 says to INCREASE 6-MP dose if taken with allopurinol. Shouldn't this say DECREASE 6-MP dose? Am I misinterpreting what it is saying?

Yeah it's just saying is that the concentrations of 6-MP and azathio in the body increase when you combine them with allopurinol because they aren't broken down by XO. It's just a classic FA fragment sentence. You would decrease doses in this case.

 

[Phloston]

If you do find it confusing, you can submit a suggestion to the errata team for a rewording and it will be considered.