alpha 2 angonist and analgesia

[MudPhud20XX]

Firecracker says:

alpha 2 agonist: clonidine, methyldopy, dexmedetomindine, guanfacine
—> decrease presynaptic release of NE/Epi —> reduce sympathetic outflow —> treatment for HTN or used for analgesia

Can anyone explain the role of alpha2 agnoist in analgesia? What is the mechanism? Is it associated with the reduced sympathetic outflow that you don't feel any pain?

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[Missorleans]

reduce the sympathetic reactions to pain: tachycardia, hypertension, anxiety?

 

[Phloston]

Literally just type "alpha 2 analgesia" on Google and the first thing you come up with is: http://www.ncbi.nlm.nih.gov/pubmed/7767720