Anyone palliated a primary effusion lymphoma before?

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emt409

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I'm worried boom boom isn't enough for a lesion this size. Maybe 2Gy x 5?

Background: 37yo s/p liver transplant for HCV/etoh cirrhosis who developed HH8 effusion lymphoma thereafter. Has bad CKD, so can longer get much cytotoxic therapy. CD20 negative, so can't get rituximab.

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That sounds reasonable. I have given similar palliative doses for visceral kaposi to large fields in the chest and abdomen, which is also hh8 related- never heard of this entity before. If you are giving a really large field to the abdomen, consider a bit of decadron and zofran prior to each treatment.
 
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Why try to get cute with palliation? Just do 2 Gy x 10 IMO.
 
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I'm worried boom boom isn't enough for a lesion this size. Maybe 2Gy x 5?

Background: 37yo s/p liver transplant for HCV/etoh cirrhosis who developed HH8 effusion lymphoma thereafter. Has bad CKD, so can longer get much cytotoxic therapy. CD20 negative, so can't get rituximab.

Have done 4 gy x 2 to larger fields for lymhoma. Effective quickly and shorter treatment duration than 5. Room for more with either if ever necessary, though I get the impression it probably won’t be.

Edit: to answer your initial question, no.
 
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I'm not overtly familiar with HH8 effusion lymphoma, but is it high grade lymphoma? I thought 2Gy x 2 was only used for palliating indolent lymphoma? I'd just do 2-3Gy x 5-10. Either opposed laterals or IMRT.
 
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