If you're a good enough candidate remember to be picky. Take the best job possible...and believe me, investigate the lab beforehand...ask members what they think about their work and their boss. I interviewed for about 10 lab positions after college, and got offers from about 7 of them (so I got pretty pro at this). Most interviews will ask about your prior research experience...definitely be ready to explain any projects you've done in detail and demonstrate your understanding of the techniques you learned. Come with questions...on the line...
(1) What project will I work on?
(2) Will there be independence? Can I develop my own project?
(3) What are the hours? Weekend time?
(4) Job benefits: can I take courses while a tech at the attached university (if applicable)?
(5) What's the committment: 1 year, 2 years? (it's typically two).
(6) Will I be attached to a postdoc? Who will that be?
For the most part, if you're a good candidate you'll probably only lose out in consideration if there are candidates with masters degrees also applying. Some of the positions I interviewed for varied from "take care of the mouse colony" to "sequence SNPs in cancer patients". I liked the research in some labs, but may have hated the people or (in some cases) the pay. Ultimately, I got offered a position in a new lab at a great university with great benefits, in a position where I largely function as a graduate student who also takes care of side projects more akin to "techy" stuff (i.e. molecular cloning, barf). Being a tech in a less established lab is often a better experience than a large, successful lab...more so because you can avoid the dread of having to be a post doc's slave, slash, you're given important projects that need to be done even though they aren't a lot of people to do them yet. Be picky...don't take a job that isn't intellectually stimulating or you'll just end up hating research. Also, if you get enough interviews don't feel bad about asking for more money. I got 5k/year more than I was offered initially because I knew how to play hardball. Good luck!