Originally posted by Tweetie_bird:
•Smoothie, in response to your question, that IS how resistance is conferred upon virus, right?
So, I am assuming that this is how it works. Virus A goes into body, Antibody A recognizes it, kills it. Over time, the virus, can back-mutate and transcribe and translate different combinations of it's gene (?) that codes for the specific receptor the Antibody A attaches to. Now, since the virus is wearing a cute new little dress, antibody A doesn't recognize it..and BOOM! You got resistance!
I hope that's right.
Tweetie•••
your kind of there.
First of all, what do antibody recognize?
they recognize proteins or better yet,epitopes (spell incorrectlY) Using HIV as ex., they have spike proteins which are used for ligand-receptors interactions. NOw while virus are being replicated and translated, there is a proofreading ability in DNA polermase, but is there proofreading ability in RNA polermase? NO. This allows errors to go unnotice, so when genes for spike protein (that eventually be on the lipid membrane of the HIV virus) are translated incorrectly, this is where problems arises. YOur immune goes a primary response and a secondary response. The primary response takes more time than a secondary response, so the virus uses that it's advantage while it's tons of virions produced, which each may have different mutations, and population growth is rapid, the immune system can't respond quickly enough to the various different epitopes that are being produced.