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Here is the most up to date collection of errata, corrections, etc. for the Companion to the Quick Compendium of Clinical Pathology. As always suggestions/comments are welcome. Thanks again to all who have contributed, especially deschutes, Nilf, 112641, rodak, and Gyric.
Geo
Chapter 1
1. answer should read "Rate of enzyme activity varies linearly with substrate concentration UNTIL enzyme is fully saturated.
* 23. should be "in vivo half life" instead of in vitro.
29. There are two Cs in the answer choices. (print only)
43. Choices A and D are identical; it's not really a mistake because both serous cystadenomas and solid-cystic tumors have identical amylase/CEA/CA19-9 pattern, but it's unusual to have two identical answer choices. Also extra A in question (at least online version)
78. 'hyperparthyroidism' should be hyperparathyroidism.
83. Choice B and the explanation. pH of 7.0. Everywhere pH 7.0 is (in both the question (choices B and C) and the explanation) it should be replaced by pH 7.40, such as the general range is 7.40 to 7.44
98. explanation: 'rhabomyolysis' should be rhabdomyolysis
143. The explanation states: 'The legal limits (of ethanol) vary by state, but are typically in the range of 0.8-1.0% should say .08-0.1%
146. The math is wrong. The answer should be 140x2 + 10/2.5 + 180/18 = 294. Change choice E in the question stem and answer to 294 mOsm/L and correct the misplaced decimal point in the formula, which should state ..180/18 rather than 180/1.8.
179. Last word of answer explanation should be months not weeks.
184. Choice B should read classical symptoms of diabetes and casual plasma glucose greater than 150 mg/dL.
206. answer explanation "Normetanephrine is metabolized to normetanephrine" should read norepinephrine is metabolized to normetanephrine.
209. 'Hyperthyroidism' in the question stem should be replaced with 'hypothyroidism'.
Chapter 2
67. explanation states: 'While both Factor V and Factor VII are labile in vitro, Factor VII is most labile in vivo.' It should say: 'While both Factor V and Factor VIII are labile in vitro, Factor VII is most labile in vivo.'
79. Which of the following indications is an appropriate usage of irradiated products?
A. cellular products to immunocompromised hosts
B. granulocyte concentrates to prevent neutropenic sepsis
C. prevention of alloimmunization in platelets
D. red blood cells to prevent CMV transmission
E. red blood cells to prevent recurrent febrile nonhemolytic transfusion reactions
A. cellular products to immunocompromised hosts.
The only clear indication for irradiation is to prevent transfusion-associated graft v. host disease. By irradiating white blood cells, they are rendered incapable of engrafting in an immunocompromised host. Irradiated products do not prevent CMV transmission, alloimmunization, or recurrent febrile non-hemolytic transfusion reactions, like leukoreduction does. Furthermore, while irradiation of granulocyte products is indicated to prevent graft v. host the irradiation does not prevent sepsis directly.
Chapter 3
39. Choice B in the question should be E. coli rather than gram negative anaerobes. Also the online answer lacks the complete answer. It should state C. N. meningitidis.
53. explanation should read "Coag-negative staph"
71. question stem should have 'except'.
* 91. in explanation, answer reads "B. the period between the disappearance of HBsAg and appearance of HBcAb.", but should read "... appearance of HBsAb"
* 181. question should be reworded from:
Which of the following dematiaceous molds is responsible for chromoblastomycosis?
A. Fonseca
B. Phialophora
C. Cladosporiom
D. Wangiella
E. Exophiala
to:
Which of the following dematiaceous molds is responsible for chromoblastomycosis?
A. Fonseca
B. Phialophora
C. Cladosporium
D. A & B
E. A, B, C
also, in the explanation "dematiaceous" is misspelled.
* 187. The question should read "Which of the following stains the cell wall of cryptococcus?"
* 196. The explanation should be changed to:
B. white.
MacConkey agar is both selective for gram-negative organisms and differential for lactose fermenters v. non-lactose fermenters. The lactose non-fermenters appear as white colonies, and include organisms such as Pseudomonas, Serratia, and Burkholderia
* 229. question: "What is the optimal growth temperature for Pseudomonas?" should be changed to "Growth at which of the following temperatures helps differentiate Pseudomonas aeruginosa" from most other species of Pseudomonas? and the explanation should be changed to:
"Pseudomonas aeruginosa can grow at a temperature that would induce the expression of heat-shock proteins in most other bacteria. Despite the wide temperature growth range for Pseudomonas, P. putida and P. fluorescens will not grow at 42°C."
Chapter 4
* 74. Question choice A "--/-alpha" should be "--/alpha alpha"
* 75. Question choice C "lot Hct" should be "low Hct"
* 98. Explanation reads "...coated with antibodies rather than delivered to ..." and should be changed to "...coated with antibodies then delivered to..."
* 112. Explanation reads "...as neutropenia with affecting lymphocyte production..." and should be changed to "...as neutropenia without affecting lymphocyte production..." Also, Kostmann is misspelled as "Kostmannn" throughout the explanation (at least in the electronic version).
Chapter 5
43. type 2N is best considered autosomal recessive, not dominant, as the answer indicates. The correct answer should be A. autosomal recessive and the explanation should reflect that, i.e. the last word in the answer explanation should be recessive.
Chapter 6
50. explanation should read "All are associated with drug-induced lupus, which in turn is highly associated with anti-nuclear and anti-histone antibodies.
51. last line of explanation should read "activate cellular immunity", rather than active cellular immunity.
Chapter 7
* 25. Answer written as "B. 85%." should be "C. 85%"
* 45. Explanation is confusing. It reads "Birt-Hogg-Dube is not associated with pseudohermaphroditism and renal tumors, but Denys-Drash syndrome is.", but is probably better stated as "Birt-Hogg-Dube is not associated with the combination of pseudohermaphroditism and renal tumors, but Denys-Drash syndrome is.", since BHD is associated with renal tumors, but not associated with pseudohermaphroditism.
* 60. Explanation reads "...with Ewing sarcoma is t(11;22)(q24;a12)." and should read "...with Ewing sarcoma is t(11;22)(q24;q12)."
* 63. In the answer "Beckwith-Weidemann" should be spelled "Beckwith-Wiedemann"
* 65. The question is wrong. Currently it reads:
Synovial sarcoma is associated with the translocation t(X;18) resulting in a SYT-SSX fusion. Which of the following statements is correct?
A. SYT-SSX2 is associated more with biphasic synovial sarcoma
B. SYT-SSX1 is associated more with monophasic synovial sarcoma
C. SYT-SSX2 is associated more with monophasic synovial sarcoma
D. SYT-SSX1 is associated more with biphasic synovial sarcoma
E. none of the above are true
and should be changed to:
Synovial sarcoma is associated with the translocation t(X;18) resulting in a SYT-SSX fusion. Which of the following statements is correct?
A. SYT-SSX1 is associated more with biphasic synovial sarcoma
B. SYT-SSX2 is associated more with monophasic synovial sarcoma
C. SYT-SSX1 is associated more with monophasic synovial sarcoma
D. A & B
E. A, B, C
and the answer will be "D. A & B." Same explanation.
* 72. Explanation states "Normal (unaffected non-carrier) individuals usually have more than 26 CAG repeats..." but should read "Normal (unaffected non-carrier) individuals usually have less than 26 CAG repeats"
* 125. Explanation states ""loss of parental DNA leads to Prader-Willi" it should be "loss of paternal DNA leads to Prader-Willi"
Geo
