Have you purchased a home before? First of all, 26% is the marginal tax rate... So many people don't understand that only part of your income falls in that range. Secondly, $200k will never be $400k for a physician. You clearly have not been following the trends if you don't realize that physician income isn't keeping up with inflation. It's going down, but I digress. Let's assume a state that has income tax, since Florida is an awful state to practice medicine. Assuming $140k annual income after taxes, that's $11,667. Less the mortgage = $6,967. Here's the big one. You forget med school loans. Assuming $100-200k (average is around $150k) in debt the loan payment will be between $1-2k per month leaving you with $5,467. Less the lease payment for 2 mid-level luxury cars (e class or 5 series leases run at least $500 each) = $4,467. Less food and clothing for a family of 4 = $3,467. Less gas for vehicles, internet, cable, cell phone, utilities, etc = $2,467. Suddenly that huge physician income isn't so large is it? This is excluding miscellaneous expenses for a family, such as piano lessons, tennis lessons, vacation, gym memberships, country club memberships, entertainment, electronics, etc.
Budgeting is key, but you have to budget literally everything. You can't just say "We have $147,000 left over. $57k for mortgage leaves $90k a year. That's plenty!" That's how many physicians think and that's why they are known for being bad with money. My personal strategy is to set aside a third of my pretax income as my limit for spending (including mortgage).
P.S. Many lenders won't even approve you for 5x your annual income (after the recent housing mess) and especially not if you are hundreds of thousands of dollars in debt from med school. The above example was for 4x your annual income and you can see how little flexibility you actually have.