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Disclaimer: this question is based of a UW item
In forming pigmented gallstones, am I correct in saying that bilirubin comes from chronic hemolysis, whereas the bile salts in the stones come from 7-a-hydroxylase formation in the liver? And further, that the formation of the bile salts tends to DECREASE the formation of the stones, as the bilirubin becomes more soluble? And finally, is all the bile in a pigment stone conjugated (via b-glucoronidase) or is there any unconjugated (I think not, just wanted to check)
Thanks!
In forming pigmented gallstones, am I correct in saying that bilirubin comes from chronic hemolysis, whereas the bile salts in the stones come from 7-a-hydroxylase formation in the liver? And further, that the formation of the bile salts tends to DECREASE the formation of the stones, as the bilirubin becomes more soluble? And finally, is all the bile in a pigment stone conjugated (via b-glucoronidase) or is there any unconjugated (I think not, just wanted to check)
Thanks!