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Hello all,
I am currently on my OB rotation and an attending asked me to look up info because one of our patients who has a significant family hx of ovarian ca.
She is 24y/o G1P1 otherwise healthy, non-smoker. (sister died at age 25, maternal aunt died at 31, cousin died at 28 from stromal ovarian CA) and she is BRCA1 positive wants to take OCPs for ovarian CA protection but has a Mirena IUD for contraception.
I found this article in NEJM showing that OCPs decrease ovarian CA rates in BRCA1 positive patients:
http://content.nejm.org/cgi/content/abstract/339/7/424
But, I can find absolutely no literature on mirena/OCP interaction and I would be really appreciative if someone could point me in the right direction.
My initial thought would be that there is no interaction since the intrauterine devices do not cause elevated peripheral progesterone levels so there would likely be no interaction but that was my best guess. Thanks
I am currently on my OB rotation and an attending asked me to look up info because one of our patients who has a significant family hx of ovarian ca.
She is 24y/o G1P1 otherwise healthy, non-smoker. (sister died at age 25, maternal aunt died at 31, cousin died at 28 from stromal ovarian CA) and she is BRCA1 positive wants to take OCPs for ovarian CA protection but has a Mirena IUD for contraception.
I found this article in NEJM showing that OCPs decrease ovarian CA rates in BRCA1 positive patients:
http://content.nejm.org/cgi/content/abstract/339/7/424
But, I can find absolutely no literature on mirena/OCP interaction and I would be really appreciative if someone could point me in the right direction.
My initial thought would be that there is no interaction since the intrauterine devices do not cause elevated peripheral progesterone levels so there would likely be no interaction but that was my best guess. Thanks