well I have to prepare lecture about surgical treatment of breast ca (for a group of doctors) and have no idea where to find necessary informations
The NCCN site is probably the easiest to manuever around if you don't have a textbook available. If you can access a medical library or borrow one, the best, easiest to understand book is the MD Anderson Handbook of Surgical Oncology. The first two chapters are about the management of breast cancer.
http://www.amazon.com/M-D-Anderson-...ef=sr_1_1/002-8541072-6407262?ie=UTF8&s=books It is new, easy to understand and offers info on current controversies in the field.
Remember when you talk about "breast cancer" you are talking about a large range of tumors with different biological behaviors. It is likely easiest for you to divide your discussion into the Surgical Management of Non-Invasive and Invasive Breast Cancers. So essentially DCIS/LCIS vs IDC/ILC and the "others" (ie, tubular, papillary, metastatic, etc.) We don't necessarily treat all patients with DCIS the same, just as we don't treat all patients with lobular carcinoma the same. However, surgically things haven't changed as much since the advent of Breast conservation as things have in the field of medical oncology (which is really focusing on tumor biology, including reecptor status).
Then you'll need to talk about Breast Conserving Treatment (BCT) (ie, partial mastectomy/lumpectomy/quadrantectomy/tylectomy) vs Mastectomy (simple vs Modified Radical. The radical Halstead or Patey operations are not really done anymore because there is no evidence that it improves survival or decreases local recurrence over the MRM).
BCT vs Mastectomy decision tree comes down to a few factors which the surgeon needs to consider:
Favors BCT
relatively small tumors (based on breast size)
single quadrant
able to tolerate, get to Rad Tx
Can get clear margins
Patient preference
Favors Mastectomy
relatively large tumor
multi-centric
Unable to tolerate radiation
Multiple attempts with + margins
Patient preference
Remember that the data from NSABP-32 found that partial mastectomy + radiation treatment = mastectomy in terms of overall survival. There is an increased risk of recurrence in the BCT group over mastectomy, but radiation reduces this by 50%. If you add hormonal blockade (such as with Tamoxifen or Raloxifene) for the premenopausal women or with an Aromatase Inhibitor (such as Femara, Aromasin, etc.) for the post-menopausal, it further reduces the risk of local recurrence yet another 43%. The risk of local recurrence is NOT 0% with a mastectomy - some tissue is left behind or can recur in the scar.
You'll also perhaps want to talk about the management of the axilla. Technically, in situ carcinoma does not have the ability (yet) to spread so the "board answer" is that you leave the axilla alone in DCIS or LCIS. However, I will tell you that in practice, women with large palpable DCIS/LCIS tumors, "microinvasion" in a DCIS/LCIS (which is invasion in my book) or high-grade DCIS will get a sentinel lymph node biopsy and possible axillary clearance. Patients with clinically palpable nodes can undergo frozen section of the removed node and then axillary clearance if the FS is positive.
Patients having a MRM get the axilla cleared at the same time, as do patients with positive sentinel nodes (SLN). Patients with invasive cancer need their axilla staged - so they get SLN biopsy even if they are getting BCT. The number of nodes determines the stage of the cancer and may influence treatment (medical oncology stuff).
Finally, while it is not surgical management, in practice patients over 70, especially those with multiple medical problems, may not be offered radiation routinely after BCT as the risk of recurrence given their lifespan is low.
Does that make sense? Discuss invasive vs non-invasive cancer, when you would do BCT vs mastectomy, and what to do about the axilla. For extra points you can talk about prophylactic mastectomies in gene positive patients, patients with lobular cancer and patients with high anxiety; then there is the issue of reconstruction - which is almost always done immediately these days unless the patient is undergoing radiation (in which case its probably better to wait until rads is done to preserve the flap or give the best cosmetic appearance).