I live in the area (which I must add is far from being a dump) and do know a couple people who make the commute everyday. They assure me that it's no trouble at all. They've told me that you might get small nuisances, like the occasion pull-over to do a quick search, or back-ups on holidays like thanksgiving, but it's definitely tolerable and you will get people every year who do it.
They also always speak highly of the school, on a side note.