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carbamazepine, phenytoin, and valproic acid

Discussion in 'Step I' started by lipofuscin232, Jun 14, 2008.

  1. lipofuscin232

    2+ Year Member

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    Does anybody have a good way of remembering the toxicities of these...I can never keep these straight! Thanks for the help!
     
  2. agranulocytosis

    Physician 10+ Year Member

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    I think phenytoin is relatively straight forward because it's the only antiepileptic with gum hyperplasia. Carbamazapine = my user ID :). Clozapine I think is the only other drug to cause agranulocytosis. VaLproate = elevated LFT's. But these are just the basic ones, and know which ones induce P-450.
     
  3. obiwan

    obiwan Junior Member
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    also important, valproate = increased risk of neural tube defects
     
  4. 45408

    45408 aw buddy
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    specifically spina bifida
     
  5. osli

    osli Senior Member
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    Mirtazapine is usually listed as well, and others reported include methimazole, chloramphenicol, and sometimes even penicillin and some NSAIDS.
     
  6. Tiger26

    Tiger26 Senior Member
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    Pretty sure that I learned that one on each old pharm test from 2000-2007
     
  7. Instatewaiter

    Instatewaiter But... there's a troponin
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    and PTU and colchicine
     
  8. osli

    osli Senior Member
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    Yeah, colchicine! I didn't know about PTU though... is it listed specifically, or just lumped together with "anti-thyroids" (i.e., methimazole)?
     
  9. NJMD

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    Quinidine causes agranulocytosis as well.
     

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