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Discussion in 'Medical Students - MD' started by sw2kool, Apr 24, 2012.
Does the blood have a net negative charge, positive charge or is it neutral?
There is net plasma electroneutrality. -Guyton, p400
No this is not correct. All cells in the body have a net positive charge outside or net negative inside dept on how you want to look at it. Most cells use the NA/K ATPase antiporter to accomplish this. 3 Na+ out 2 K in. The Na gradient drives everything from nerve action potentials to renal filtrate modulation to cardiac contractility via driving calcium antiporters. This is clear when looking at a neuron membrane potential of ~ -90mV w respect to the inside. If not for electrical gradients EKGs and EEGs would not work. There are several examples of cells taking differential advantage of concentration or electrical gradients to accomplish work. I'm a little low on examples bc this post is being written while on a bathroom break (sdn>sports page)
As for blood, the coagulative components tend to have a negative charge but the serum over all is slightly basic and the auto ionizing property of water will neutralize charge. The reason for the negative charge is anti coagulation when interacting (or not) with negative charges on healthy endothelium
A net neutrality within compartments should not be confused with absence of charge separation.