Clinical Case Management - Locally Advanced Rectal Cancer

[seper]

This is the most relevant published phase III study, to my knowledge. Prompt surgery after CRT works the best.

Effect of Interval (7 or 11 weeks) Between Neoadjuvant Radiochemotherapy and Surgery on Complete Pathologic Response in Rectal Cancer: A Multicenter, Randomized, Controlled Trial (GRECCAR-6) - PubMed

Purpose A pathologic complete response (pCR; ypT0N0) of a rectal tumor after neoadjuvant radiochemotherapy (RCT) is associated with an excellent prognosis. Several retrospective studies have investigated the effect of increasing the delay after RCT. The aim of this study was to evaluate the...

www.ncbi.nlm.nih.gov

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[Mandelin Rain]

I kind of just missed routine 3DCRT to the prostate, but I have to imagine those early dose escalated plans likely gave 60Gy to the circumferential rectum routinely. Not to sound nihilistic about it, but I would never expect 60Gy to the rectum to kill someone.