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Most of these drugs are sold for a tenth the cost, or less, in other countries. I think the best way to handle this is not through an arbitrary cap, but by allowing US citizens to purchase drugs from other first-world countries, as prices are artificially inflated in the United States compared with the rest of the world.This idea would work...
... if we also federalized the manufacture of medications. If drug companies can't get paid for making the meds then they just won't make them. It happens all the time leading to various drug shortages; manufacturers stop producing the meds for whatever reason. This would be a very strong financial disincentive. Or they just wouldn't get marketed in the US.
Or the government could step in and pay the difference... which is also unfeasible.
Wonder how they plan to make that work with chemo or other drug regimens that are thousands of dollars per treatment.
Yes, lets just set an arbitrary cap on how much something is worth. I'm sure it will work.
Does the article not say that the $250 is on what insurance companies can charge patients out of pocket? This would not cap what insurance companies are required to actually pay for the drugs. I wonder how many insurance plans already have monthly caps for out of pocket expenses that are somewhat close to this number?
Or they won't change deductibles but they'll just increase their premiums.Then insurance companies will simply not cover those drugs. Nobody is in the business of losing money.
I'm ok with that. See the Pyrimethamine story. Cost controls make sense.
Wonder how they plan to make that work with chemo or other drug regimens that are thousands of dollars per treatment.
Yes, lets just set an arbitrary cap on how much something is worth. I'm sure it will work.
This idea would work...
... if we also federalized the manufacture of medications. If drug companies can't get paid for making the meds then they just won't make them. It happens all the time leading to various drug shortages; manufacturers stop producing the meds for whatever reason. This would be a very strong financial disincentive. Or they just wouldn't get marketed in the US.
Or the government could step in and pay the difference... which is also unfeasible.
It's more about the law of unintended consequences. If you set a $250 limit on drugs, there's going to be a lot of investment cash pulled out of cancer drug development, for instance, as cancer drugs need to sell for astronomical amounts to be profitable since they aren't exactly something you can sell to the public at large like antidepressants or stimulants.I'm ok with that. See the Pyrimethamine story. Cost controls make sense.
she should propose a cap on how often we have to see her ugly face on TV
What is worth investigating is why some 1950's/60's antimalarial is granted a patent and exclusivity for a whole phylum of parasites (in 2002),and why there is exclusivity beyond the usual 7 year period?
Then insurance companies will simply not cover those drugs. Nobody is in the business of losing money.
I'm ok with that. See the Pyrimethamine story. Cost controls make sense.
It is "$250 monthly cap on prescription drugs for patients with chronic or serious medical conditions." Again, see the case behind the jacking up of Pyrimethamine from $13.50 a pill to $750 a pill (a 5,500% increase). So lay off the R&D line, because the drug works perfectly fine for the condition it treats for decades and are happy with it. She has other ideas too, like letting Medicare negotiate over drug prices. The cap isn't the only idea in the article.It's more about the law of unintended consequences. If you set a $250 limit on drugs, there's going to be a lot of investment cash pulled out of cancer drug development, for instance, as cancer drugs need to sell for astronomical amounts to be profitable since they aren't exactly something you can sell to the public at large like antidepressants or stimulants.
I think you need to adjust your tinfoil Tea Party hat. Medicare and Medicaid, which are government programs, pay for these drugs. Feel free not to take icky communist government student loans for med school.hell just nationalize it all. let's just move to communism, that works so well for all involved, as history has shown
In this particular case, it is pretty messed up, as this should be an easily obtainable, generic drug at its current age. But new drugs are where the problem comes in. Cancer, for instance, falls under the umbrella of "chronic or serious medical condition" for sure, and a $250 limit would certainly cut private investment into new cancer treatments.It is "$250 monthly cap on prescription drugs for patients with chronic or serious medical conditions." Again, see the case behind the jacking up of Pyrimethamine from $13.50 a pill to $750 a pill (a 5,500% increase). So lay off the R&D line, because the drug works perfectly fine for the condition it treats for decades and are happy with it. She has other ideas too, like letting Medicare negotiate over drug prices. The cap isn't the only idea in the article.
Every law has unintended consequences. The same was said for FMLA, but I'm glad it exists, in case it is needed.
I think you need to adjust your tinfoil Tea Party hat. Medicare and Medicaid, which are government programs, pay for these drugs. Feel free not to take icky communist government student loans for med school.
I'm sure they'll say it is R&D for future drugs. When even the CNBC anchors look at him like he's a disgusting person, you know he is a pig.Sure, a drug company won't make a drug that won't make them money. But it's hard to conceive that Daraprim's former manufacturer was able to make and sell a drug for $13.50 a pill (formerly $1), but the new company can't make that same drug profitably for less than $750? And the new company DOESN'T have the R&D investment to write off.
The other option is the drug just stops being made, as has happened with things like antivenoms as of late, as it wasn't profitable enough, so rather than jacking up the price 5,000% they just stopped making it entirely.I'm sure they'll say it is R&D for future drugs. When even the CNBC anchors look at him like he's a disgusting person, you know he is a pig.
Same thing happened with a gout drug, Colchicine. Pyrimethamine isn't the only example. Like I said, in the article, she has other ideas. If patients can't afford the drug thats a problem, and for some drugs its only a few more months of life.In this particular case, it is pretty messed up, as this should be an easily obtainable, generic drug at its current age. But new drugs are where the problem comes in. Cancer, for instance, falls under the umbrella of "chronic or serious medical condition" for sure, and a $250 limit would certainly cut private investment into new cancer treatments.
What I'm not getting is how this drug isn't just generic by now- there's no way it's still under patent protection. Is it just difficult to produce and only GSK had the process to make it?@DokterMom Right. The research for pyrimethamine was done in the 1950's by Gertrude Elion, and the development cost was borne by Burroughs-Wellcome, later part of GlaxoSmithKline. The move was made to increase profits for a small pharmaceutical company to appease investors over previous misappropriations. So basically a small captive market of patients and their insurance companies, and Medicare/Medicaid are being used to pay for someone's questionable business decisions. Of course, indirectly, that means that the rest of us pay for this as well, in increased premiums and a proportion of taxes.
Pyrimethamine was made by Impax, but since their market isn't parasitic drugs they sold it to Turing Pharmaceuticals, founded by a former hedge fund guy. Don't compare a once in a lifetime need for antivenom to this drug.The other option is the drug just stops being made, as has happened with things like antivenoms as of late, as it wasn't profitable enough, so rather than jacking up the price 5,000% they just stopped making it entirely.
http://www.iflscience.com/health-and-medicine/snakebite-anti-venom-track-run-out-next-year
http://www.houstonchronicle.com/new...e-antidote-shortage-poses-ethical-6352084.php
i believe it is generic.What I'm not getting is how this drug isn't just generic by now- there's no way it's still under patent protection. Is it just difficult to produce and only GSK had the process to make it?
Okay, me too. Like I said above, I really don't get that part. I posted what I posted above hoping someone here understood the process. I googled the patents on it, and I found one for the process of manufacture, and one for the use of it as an anti-parasitic, in addition to some about formulation, whihc did not seem applicable. Based on my very limited understanding of this subject, patents are only good for 20 years, and exclusivity for only seven.What I'm not getting is how this drug isn't just generic by now- there's no way it's still under patent protection. Is it just difficult to produce and only GSK had the process to make it?
Pyrimethamine was made by Impax, but since their market isn't parasitic drugs they sold it to Turing Pharmaceuticals, founded by a former hedge fund guy. Don't compare a once in a lifetime need for antivenom to this drug.
I think it's fully appropriate to compare it to antivenom, which has a much larger prescriptive need (5 million people a year) than this medicine, and the loss of which will cause potentially millions of deaths. What's the difference between a company jacking up the price of antivenom to, say, $250,000 a dose (a 5,000% increase) and this guy charging $750 a tablet for this drug? Well, there is a big difference- rather than jack up prices and deal with public backlash, GSK just let the drug die, because they knew that jacking the price up by 5 or even 10 times, which would make it profitable enough to keep around to investors, would cause a massive public backlash and be a PR disaster.i believe it is generic.
Looking into it, it's non-scheduled, but here's the problems with another company making it:Okay, me too. Like I said above, I really don't get that part. I posted what I posted above hoping someone here understood the process. I googled the patents on it, and I found one for the process of manufacture, and one for the use of it as an anti-parasitic, in addition to some about formulation, whihc did not seem applicable. Based on my very limited understanding of this subject, patents are only good for 20 years, and exclusivity for only seven.
I might have misunderstood what I read, but that's the gist of it.
Looking at the synthesis process in the patents, it doesn't look all that difficult. It is made in India cheaply.
I have mixed feelings.
The easiest way to fix this would seriously be to just let us order our drugs from Canadian, British, or Australian pharmacies. Then we don't have to deal with blanket price controls or higher premiums or special programs- just give people freedom of choice and everything will correct itself.I have patients who can't buy their inhalers. Which are all expensive. No generics. When the patent is up the companies just change things around and continue charging an arm and a leg. Most prescription drug benefits require high out of pocket expenditures before kicking in.
With that said blanket price controls are a bad idea and cause shortages in product and distortion in the market in general.
Not everyone needs price controls on out of pocket drug costs and to cap this for everyone in all plans would be stupid. This would lead to higher premiums as everyone would need to further subsidize this cost.
I might humbly suggest out of pocket caps, if any, based on income. You could apply for special programs. The cost for these populations who need help for mess could be paid in part by higher premiums and also in part government subsidies.
This drug is way off patent though. It's so old it's not even scheduled.@Mad Jack : Yeah, I read that too. First of all, I think that she's wrong, in that there are still patents. A trivial point, since the economic argument is the crux, but I think it should be pointed out.
Secondly, it doesn't require building a new factory to synthesize an organic molecule. Another pharmaceutical company could produce it without a huge re-allocation of resources. I get her point, but I think that she's making a gross generalization to convey the issue.
The easiest way to fix this would seriously be to just let us order our drugs from Canadian, British, or Australian pharmacies. Then we don't have to deal with blanket price controls or higher premiums or special programs- just give people freedom of choice and everything will correct itself.
The other option is the drug just stops being made, as has happened with things like antivenoms as of late, as it wasn't profitable enough, so rather than jacking up the price 5,000% they just stopped making it entirely.
Because of government regulations that allow politically connected scum to regulate away all competition.What I'm not getting is how this drug isn't just generic by now- there's no way it's still under patent protection. Is it just difficult to produce and only GSK had the process to make it?
I know this sounds like communism (Heck, didn't the communists actually DO this?) -- But wouldn't it make sense for the government to pay a company to make these necessary drugs at a reasonable profit, then resell them at a reasonable cost to the people that need them?
Because literally every major historical example of this type of system failed completely and utterlyyeah that's not communism or anything. why not just have the government set an acceptable price on all goods.
why even deal with prices, why not just have the government distribute all goods as they see fit?
It should be free marketThere is no free market when it comes to healthcare. Prices are unknown until after you receive your care. If I ever ended up in the ER, I would probably refuse some of what they would do because a good portion of it is medicolegal nonsense forced upon them by outside forces
There are patents on it. It isn't clear if any of those patents are held by any of the companies that have had ownership of this drug in recent years (it has changed hands a few times since GSK sold it), or if the ones within the 20 year limit are applicable to its manufacture and sale as a pharmaceutical. I am not sure what you mean about the other part.This drug is way off patent though. It's so old it's not even scheduled.
I would be okay with that. If we had a government owned company that made off-label, unprofitable drugs and sold them at cost it would be perfectly reasonable, as corporations have no incentive to do so for their shareholders.I know this sounds like communism (Heck, didn't the communists actually DO this?) -- But wouldn't it make sense for the government to pay a company to make these necessary drugs at a reasonable profit, then resell them at a reasonable cost to the people that need them?
I know this sounds like communism (Heck, didn't the communists actually DO this?) -- But wouldn't it make sense for the government to pay a company to make these necessary drugs at a reasonable profit, then resell them at a reasonable cost to the people that need them?
No patent currently exists for the drug. All he bought was the brand name and supply chain for it, anyone else could manufacture it right now.There are patents on it. It isn't clear if any of those patents are held by any of the companies that have had ownership of this drug in recent years (it has changed hands a few times since GSK sold it), or if the ones within the 20 year limit are applicable to its manufacture and sale as a pharmaceutical. I am not sure what you mean about the other part.
According to the list of Orphan Drugs that I downloaded from the FDA, pyrimethamine wasn't specifically noted, except as an adjunct to be used with sulfadiazine to be used in the treatment of toxo. I am not sure how this bears out in terms of maintaining exclusivity, if at all.
Because literally every major historical example of this type of system failed completely and utterly
I would be okay with that. If we had a government owned company that made off-label, unprofitable drugs and sold them at cost it would be perfectly reasonable, as corporations have no incentive to do so for their shareholders.