Complete hydatidiform mole -> choriocarnioma %?

[Staradmiral]

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Alright I absolutely do not know what is the correct % of complete hydatidiform mole that progresses to choriocarcinoma.

Goljan says 20%
USMLE world says 20%
Medscape says 20%

Kaplan Qbank says 2%
Robbins says 2%
Wikipedia says 2% (if that counts)

I have absolutely no idea what is correct and really hope this does not show up on the step 1.

Anyone know which is right? for certain?

 

[phoenix89]

Pathoma also has 2-3%. They wont be asking you the exact percentage, just go in the exam knowing that a Complete Mole has a significant chance of progressing to Choriocarcinoma; whereas an Incomplete Mole has a minimal (but still a small) chance to progress.

That's what the examiners would want you to know.

 

[thinkenergy]

2-3% risk into choriocarcinoma but 20% risk into an invasive mole. MC complication of a complete mole = invasive mole NOT choriocarcinoma.

 

[thinkenergy]

Pathoma also has 2-3%. They wont be asking you the exact percentage, just go in the exam knowing that a Complete Mole has a significant chance of progressing to Choriocarcinoma; whereas an Incomplete Mole has a minimal (but still a small) chance to progress.

That's what the examiners would want you to know.

I disagree, there is more that USMLE requires you to know about molar pregnancy

 

[Phloston]

Robbin's says 2% chance of progression for complete mole and "rarely" for partial mole (p. 735, 8th ed.).

It then goes on to say "Overall, 80% to 90% of moles do not recur after thorough curettage; 10% of complete moles are invasive, but not more than 2% to 3% give rise to choriocarcinoma. Partial moles rarely give rise to choriocarcinomas...Approximately 50% of choriocarcinomas arise in complete hyaditidiform moles; about 25% arise after an abortion, and most of the remainder occur during what had been a normal pregnancy" (736-7).

Also know that haematogenous spread to the lungs is the high-yield point regarding mets.