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- Jan 31, 2016
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Hi everyone
If my understanding is correct, 17-hydroxylase deficiency presents with diminished secondary sexual characteristics due to reduced adrenal and gonadal synthesis of androstenedione and DHEA, which are precursors for testosterone and oestrogen. Is this correct, or are there different enzymes in the gonads and adrenal cortex? Also, does Addison's disease present with the same thing, because you get loss of androgen production? I imagine the gonads make enough to compensate, but I want to make sure.
If my understanding is correct, 17-hydroxylase deficiency presents with diminished secondary sexual characteristics due to reduced adrenal and gonadal synthesis of androstenedione and DHEA, which are precursors for testosterone and oestrogen. Is this correct, or are there different enzymes in the gonads and adrenal cortex? Also, does Addison's disease present with the same thing, because you get loss of androgen production? I imagine the gonads make enough to compensate, but I want to make sure.