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On one of the other threads, a poster had mentioned that while steric hindrance reduces nucleophilicity (if that's a word), it has no impact on basicity.
Nucleophile is attracted to a positive charge, a base donates its electron pair so therefore it would also like a positive charge.
Consider OH- - it is a weak base, but it also a nucelophile. In elimination reactions as a base it would attack the H, but in a substitution reaction it would directly attack the polar C atom.
Can anyone shed more light on this?
Nucleophile is attracted to a positive charge, a base donates its electron pair so therefore it would also like a positive charge.
Consider OH- - it is a weak base, but it also a nucelophile. In elimination reactions as a base it would attack the H, but in a substitution reaction it would directly attack the polar C atom.
Can anyone shed more light on this?