Discrepancy in EK 1001 Bio and BR Bio

[MCATMadness]

in EK bio, it says that when adding in oligomycin (which blocks the Fo subunit of the ATPase)... the ETC of the cell stops, etc BUT the cell will still try to produce aerobically bc after all, it is still in aerobic conditions.

in BR Bio (Section 7, passage 1, question 2) it says the cell switches to anaerobic respiration to try to alleviate the effects of oligomycin.

anyone else notice this?

thoughts?

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[jphwki82]

in EK bio, it says that when adding in oligomycin (which blocks the Fo subunit of the ATPase)... the ETC of the cell stops, etc BUT the cell will still try to produce aerobically bc after all, it is still in aerobic conditions.

in BR Bio (Section 7, passage 1, question 2) it says the cell switches to anaerobic respiration to try to alleviate the effects of oligomycin.

anyone else notice this?

thoughts?

Oligomycin causes a build up of protons, and eventually the cell is going to stop oxidative phosphorylation b/c it becomes overwhelmed by the gradient. If the cell is still in need of energy (ATP), then it will revert to glycolysis to get its ATP via substrate level phosphorylation. At some point, the protein complexes are going to cease pumping protons into the inner mtc membrane, and NADH will accumulate. Accumulation of NADH will inhibit the TCA cycle via Isocitrate Dehydrogenase, which is a key regulation step in that pathway. They are both correct in their reasoning. The glycolytic pathway will proceed in the presence of aerobic conditions or anaerobic conditions. Hope this helped clear that up for you.