All of the above. TwI are one of the most non-specific findings on an EKG. As with anything else, you correlate the findings with your history + physical exam. Enzymes are a bonus.
TwI can be seen with LVH, with tachycardia, with poor RPPP control, or with nothing at all.
Comparison to old EKGs is key as well.
In terms of ischemia/infarct, think of EKG changes this way:
TwI -- non-specific or ischemia
ST depressions -- ischemia
ST elevation -- infarct