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Endothelial damage leads to formation of a fibrin clot

Discussion in 'Step I' started by BlondeCookie, May 12, 2008.

  1. BlondeCookie

    BlondeCookie Senior Member 7+ Year Member

    Jul 4, 2005
    This is what I've always thought. That is, that endothelial damage (referring to bl vessel walls here), leads to formation of a fibrin clot. I was just going through some old notes, and it contradicts my logic. My notes have that...
    • endothelial damage -> activated Hageman factor (factor 12) -> thrombin -> finbrin clot degradation

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  3. DwyaneWade

    DwyaneWade Reiging *** Cynic 10+ Year Member

    May 7, 2006
    Those notes are wrong.

    It is right until the end. Thrombin (the common endproduct of both extrinsic and intrinsic clotting systems) causes fibrinogen to be converted into a fibrin clot. Plasmin late can degrade this clot to recanalize the vessel.
  4. docmd2010

    docmd2010 Senior Member 7+ Year Member

    Apr 17, 2005
    I think what activates Hageman's factor is actually exposed collagen, when the endothelial cell is damaged. This will activate the intrinsic pathway. Tissue factor (thromboplastin) and will activate the extrinisic system. The common pathway will then ensue and thrombin will form the soft tissue clot. Factor XIII will then come in and cross link the clot to make a more sturdy clot.

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