GERD is the disease.
You are comparing exposure vs. non-exposure. If you were given no other information, one would assume a case with obesity constitutes "exposure."
To make your life easier you can ignore the middle two columns.
Have disease Don't have disease
(BMI >35) 400 100
(BMI <25) 100 400
Odds ratio is the odds you get disease with the exposure in question here (BMI > 25) divided by the ratio of the control. a/b / c/d or ad/bc
Odds ratio should be 16.
At least that's how I would have done it.