There's really no secret to Step One. It is a really difficult exam because there's so much nonsense that one needs to memorize. My suggestions:
1. Use First Aid. That is the bare bones. Use it as such, and when you're using other sources, take notes into your First Aid to make it your own personal study guide.
2. Do lots of questions. These are best found (my own opinion) on QBank, Kaplan. I don't work for them (in fact, i was a princeton review teacher for mcat), but they are really great. In fact, I thought it was so useful, I'm now using it for step two (even though i really don't need a great score anymore, just to pass). Also, NMS has some questions, and tons of other sources. Doing questions helps to
a) define weaknesses
b) learn material -- make sure you spend a lot of time going over the ANSWERS/EXPLANATIONS.
3. Set up a system of study. Have a schedule which is reasonable, and reward yourself for keeping up with it. Don't beat yourself up for falling behind.
4. A study partner can really help, depending on your own situation... Even if that someone is your wife who isn't taking the test, but someone to whom you report your progress... to make sure you keep up. of course, not everyone needs this.
5. Lots of luck. Realize that it's okay that you have a hard time with exams, and that your clinical abilities will likely far surpass your memorization capabilities, and that actually makes for a fine physician.
Best of luck!