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Hey, how does G6PD deficiency lead to gallstones? Esp in children?
automaton said:yeah i think that's it. increased bilirubin in bile overwhelms gall bladder according to first aid. goljan and brs don't explain really. here's a link that says it's not understood very well but has to do with stasis and increased concentration...
http://www.emedmag.com/html/pre/gic/consults/101502.asp
razorback831 said:In one of goljan's lectures he states that hemolytic states may lead to gall bladder disease in the form on Ca bilirubinate stones....He says it in reference to SCD though
peterson said:a lot of the extravascular hemolysis diseases cause gall stones from the hyperbilirubinemia
dcpark74 said:don't you mean intravascular?
ericdamiansean said:but in G6PD def, the bite cells get destroyed (hemolysed) in the spleen (extravascular)
ericdamiansean said:but in G6PD def, the bite cells get destroyed (hemolysed) in the spleen (extravascular)
DHMO said:With G6PD deficiency, you get both intravascular and extravascular hemolysis. The oxidatively damaged hemoglobin precipitates and forms heinz bodies, which can lead to cell death by themselves. This intravascular hemolysis dumps lots of hemoglobin into the bloodstream. But the inclusions (heinz bodies) also mess up the RBC membranes, which makes them more likely to get caught in the spleen, which leads to the extravascular hemolysis. The end product of extravascular hemolysis is bilirubin. It is this excess bilirubin (from the extravascular hemolysis) that causes the stones.