Gastric Inhibitory Peptide

[dyspareunia]

FA et al say that GIP inhibits gastric secretions. The literature I've read seems to support that physiologic doses of GIP do not have any effect on gastric secretions or gastric motility.

Has anyone run into problems with this on qbanks or NBMEs?

---

Members don't see this ad.

 

[Fatalis]

only thing I was asked about it time and time again was it's role in an increase insulin release when someone takes an oral glucose load vs IV

 

[cbrons]

GIP does reduce gastric acid secretion. Directly it does this by inhibiting parietal cell H+ secretion, and indirectly it does this by inhibiting gastrin release. Its more important role (discovered later) is actually stimulating insulin release in response to elevated duodenal glucose.

Glucose / Fatty acids in duodenum --> K cells release GIP --> GIP stimulates insulin release from islet cells.

By the way, this is why the name of GIP was later changed to "glucose-dependent insulinotropic peptide."

I would be absolutely shocked if you got an exam question that tested the former rather than the latter concept.