Glucagan/cortisol question

[Monkeymaniac]

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Why is it that when glucagan and cortisol are in effect, free fatty acids are released from liver (or are they released from adipose tissues)?

Aren't they supposed to stay inside liver to generate energy (through beta oxidation and then citric cycle) since serum glucose level needs to be restored and so the sources of cellular energy generation need to be diverted to non-glucose sources?

Thanks in advance.

 

[GreenRabbit]

Free fatty acids will be released from adipocytes to travel to the liver (to provide energy via TCA / ketogenesis).

 

[Stefon1989]

Glucagon stimulates the Beta oxidation of fats and forces cells to use fats instead of glucose for energy. Because of this, ketone bodies are produced and can cause metabolic acidosis. This is why some people who have diabetes develop diabetic keto-acidosis. Cortisol is also released when there is a low level of blood glucose.
Hope that made sense!