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Glycolysis/Cell Respiration

Discussion in 'MCAT Study Question Q&A' started by Anonymous01, Feb 28, 2012.

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  1. Anonymous01

    Anonymous01 7+ Year Member

    May 18, 2008
    I found this chart searching the forums and am trying to understand a part of it:


    Why is the ATP equivalence of the NADH different for glycolysis than the equivalence for the other two steps?
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  3. chiddler

    chiddler 5+ Year Member

    Apr 6, 2010
    Because the cell has to spend energy importing NADH and pyruvate into the mitochondria innter matrix so there is less net energy per molecule. See glycerol phosphate shuttling. The NADH produced in krebs cycle on the other hand is produced within mito so no import is necessary.
  4. Anonymous01

    Anonymous01 7+ Year Member

    May 18, 2008
    Thanks for the reply!

    The ExamCrackers book says, "each NADH (depending upon the mechanism used for transport) may or may not require the hydrolysis of ATP." They were vague about it, but your explanation cleared it up.

    Thanks again!
  5. MedPR

    MedPR Banned

    Dec 1, 2011
    Just want to make sure that the net 36 ATP is per glucose, right? So the kreb's cycle only produces ~18ATP per cycle, since 1 glucose = 2 turns due to 2 pyruvates produced by glycolysis = 2 acetyl CoA's to enter into Kreb's?
  6. chiddler

    chiddler 5+ Year Member

    Apr 6, 2010
    i think less. that figure shows 18 per glucose. so half per cycle, 9. then we count 1 GTP and 1 FADH2.

    I think it's 12.
  7. milski

    milski 1K member 5+ Year Member

    Dec 30, 2009
    Where the rain grows
    Glycolysis gets you 2+4 ATP per glucose. The other 30 come from the rest of the respiration process where each step turns twice per a glucose molecule. That means that you get 6 ATP from converting NADH during entering Kerb's cycle twice which leaves you 24 for the Kerb's cycle itself or 12 for each turn.

    Depending on the literature the 36 number will vary somewhere around 32-36. You also get 2 more ATPs in prokaryotes since you lose 2 of them to cross the mitochondrial membrane in eukaryotes.
  8. Perimeter

    Perimeter 5+ Year Member

    Dec 13, 2010
    It is 29 net ATP per glucose, not 36, according to new research, not sure if the MCAT will reflect this discovery or not.
  9. theseeker4

    theseeker4 PGY 1 5+ Year Member

    I doubt you would need to worry about it, since the MCAT isn't going to ask a question about something that has so many different published numbers, or if it does it will either give you the number to assume, or give a series of options, only one of which makes any sense.
  10. SaintJude


    Jan 4, 2012
    One aspect relevant about this question is actually how this manifests between prokaryotes and eukaryotes. Prokaryotes actually produce more ATP per glucose molecule--because prokaryotes don't have to expend energy to shuttle pyruvates into mitochondria.
  11. Class1P

    Class1P 5+ Year Member

    Mar 14, 2007
    It is very unlikely that you would be asked a question about how many net ATPs are created when something happens. You'll be given that in a passage

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