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Goljan RR Page 262

Discussion in 'Step I' started by cameraGEEK, Jul 28, 2011.

  1. cameraGEEK

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    Does anyone understand on page 262 in Goljan Rapid Review why in primary fibrinolysis it is: negative D-dimers/no fibrin thrombi present but it is positive for fibrin degradation products? Thanks
     
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  3. cameraGEEK

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    Anyone?
     
  4. wanderer123

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    My understanding is primary fibrinolysis is plasmin mediated thrombus degradation WITHOUT the activation of Factor XIII, which crosslinks fibrin products to form D-dimers - fibrin is still being degraded -> degradation products.

    Secondary fibrinolysis would be the same process but AFTER Factor XIII activity and would result in D-dimer formation in addition to fibrin degradation products.
     

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