Goljan RR Page 262

[cameraGEEK]

Does anyone understand on page 262 in Goljan Rapid Review why in primary fibrinolysis it is: negative D-dimers/no fibrin thrombi present but it is positive for fibrin degradation products? Thanks

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[cameraGEEK]

Does anyone understand on page 262 in Goljan Rapid Review why in primary fibrinolysis it is: negative D-dimers/no fibrin thrombi present but it is positive for fibrin degradation products? Thanks

Anyone?

 

[wanderer123]

My understanding is primary fibrinolysis is plasmin mediated thrombus degradation WITHOUT the activation of Factor XIII, which crosslinks fibrin products to form D-dimers - fibrin is still being degraded -> degradation products.

Secondary fibrinolysis would be the same process but AFTER Factor XIII activity and would result in D-dimer formation in addition to fibrin degradation products.