taking a practice exam and got this problem wrong:
"Graves’ disease is an autoimmune disorder in which autoantibodies are formed against thyroid stimulating hormone (TSH) receptors on the thyroid gland. Patients with Graves’ disease present with resting heart rates of 105-120, elevated body temperature, increased appetite, weight loss, and insomnia. Which of the following hormone levels would be expected in a patient with Graves’ disease?"
a) decreased TSH, decreased Thyroxine (T3/4)
b) decreased TSH, increased Thyroxine (T3/4)
Answer is B.
Problem is I can reason this two ways, both of which make sense to me:
1) Autoantibodies remove TSH, which stimulates T3/4 production. Thus, removing TSH will reduce total amount of T3/4.
or
2) Looking at the patients symptoms, we see that he/she has a higher metabolic rate, which results from increased levels of T3/4, which would then negatively feedback onto the pituitary to prevent more TSH from being produced.
What is wrong about my reasoning?
Thanks!
"Graves’ disease is an autoimmune disorder in which autoantibodies are formed against thyroid stimulating hormone (TSH) receptors on the thyroid gland. Patients with Graves’ disease present with resting heart rates of 105-120, elevated body temperature, increased appetite, weight loss, and insomnia. Which of the following hormone levels would be expected in a patient with Graves’ disease?"
a) decreased TSH, decreased Thyroxine (T3/4)
b) decreased TSH, increased Thyroxine (T3/4)
Answer is B.
Problem is I can reason this two ways, both of which make sense to me:
1) Autoantibodies remove TSH, which stimulates T3/4 production. Thus, removing TSH will reduce total amount of T3/4.
or
2) Looking at the patients symptoms, we see that he/she has a higher metabolic rate, which results from increased levels of T3/4, which would then negatively feedback onto the pituitary to prevent more TSH from being produced.
What is wrong about my reasoning?
Thanks!