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In my experience, you can have great grades but you can never be assured of happiness. Of course, great grades can help. However, you cannot have bad grades and happiness. Never. As long as medicine is something you really want to do, bad grades will always put a damper on your happiness. You might spend all your time partying, hanging out with friends, doing sports, etc. but the guilt of doing poorly in school will always hang over your head and rob you of your happiness.