HIV proteins beyond gag, env, pol

[thebillsfan]

I came across a question (not on UW or anything official) that required one to know the function of the net protein. It decreases exp of MHC I, among other functions. In the past I think I've seen something about tat protein (regulates expression of reverse transcriptase I believe). Anyway, i'm wondering if its considered even moderate-yield (certainly not high-yield) to learn these protein functions.

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[Apoplexy__]

In my limited experience, UWorld Q's on HIV haven't asked about them yet. And as I'm sure you know, they're not in FA...I probably won't bother.

The only non-FA thing UWorld has asked me about the HIV genes so far is what the clinical manifestation would be upon mutating one of the genes. Wasn't too unfair a question.

 

[leftpinky]

It's nef not net. That one is super hy according to Kaplan since it decreases detection

 

[Oseltamivir]

Yes, it's the Nef factor that decreases the expression of MHC-I and increase the severity of disease. If patients are affected by a Nef -ve virus they can run a prolong and less severe course of disease.

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