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Bottom line -- either before you apply or after you start receiving IIs, but, in any case, while you still have time to address any deficiencies, make sure you get in front of any potential problems. Your post presumes the schools will take the initiative here, and the simple fact is that they won't.Medical schools do not typically check for prerequisite fulfillment until after you have taken up a final acceptance offer during the post-acceptance / pre-matriculation phase. This is when you be required to have all official transcripts sent to the medical school for this purpose. It is up to you to know the specific requirements and see that you gave met them. If they do not accept them, you can request a waiver but doesnt mean it will be granted. With the kind of issues you raise, I would think you shouldnt have a problem. You can call schools for guidance but it is just that, guidance. the decision isnt made until after you are accepted