Originally posted by hotbovie1
The previous posters are being cruel and hiding the truth from you. I believe anyone considering a surgical career deserves to know the truth....
There is an alternate biochemical pathway in all cells known as the Imhotep-Halsted pathway. Basically, this pathway utilizes the nitrogen in the air and converts it to glucose and ATP. The rate limiting enzyme (and in fact the only way to enter the pathway) is kocherdebakey pyrophosphatase. This enzyme has two active sites which must be phosphorylated in order to be activated. It has a third regulatory site which, when phosphorylated, upregulates the enzyme. This regulatory site can only be phosphoylated under conditions of low blood glucose and sleep deprivation. When upregulated, kocherdebakey pyrophosphatse also allows the Imhotep-Halsted pathway to divert nitrogen from the urea cycle, thus decreasing the production of urine.
So why can't everyone be a surgeon? Unfortunately, there is an autosomal dominant mutation of the kocherdebakey pyrophosphatase gene which renders the two active sites inactive. 95% of the population carries this mutation. These unfortuanate individuals are unequipped to be surgeons. Any attempt at a surgical career will result in pure misery.
There is another mutation, which is autosomal recessive, that only slightly alters one of the active sites. However, binding of phosphate to this site can be achieved by the consupmtion of peanut butter and crackers. 5% of the population has this mutation. These individuals can be surgeons, however, their effectivness can be limitied by the need to consume peanut butter and crackers (most OR lounges will provide peanut butter and crackers for these individuals, lest they keel over in the middle of a case).
The remaining 5% of the population has no mutation of the kocherdebakey phosphatase gene (it's on the long arm of chromosome 1). These individuals are best suited for a surgical career.
The gene was sequenced several years ago, and all members of the class of 2003 were screened for mutations at the start of our clinical rotations. Those of us who are mutation free were directed into surgery, thus explaining why so many more surgery positions filled in this year's match.
The screening test is not yet commercially available, so for now you'll have to wait until your 3rd year of medical school to be tested.
Perhaps some of the practicing surgeons on this board have been voluntarily tested, and would be willing to share the results and how the has affected them during a surgical residency.