It days to weeks before the thoracic void is filled completely, however compensatory mechanisms are at work from the time the patient is out of the OR. For a single lobectomy, the remaining lobe/lobes will expand to fill the void fairly quickly because remember that each lobe has a degree of IRV or inspiratory reserve volume. The hemidiaphragm elevates almost immediately.Remaining air is reabsorbed slowly by the pleura. Higher concentrations of inspired O2 help clear the pleural space of free air more quickly through diffusion (Room air is mostly nitrogen) by displacing nitrogen in the small airways and creating a diffusion gradient. If you seal the open bronchus adequately and optimize hemostasis in the thoracic cavity, a chest tube should not be necessary following the procedure. For a total pneumonectomy, the process is similar, if a bit slower and free air is primarily handled by the remaining parietal pleura. Hydrostatic gradients dictate the amount of pleural fluid which will fill the remaining space not occupied by expanded remaining lung.