If it's a renal disease that decreases GFR then I would think you would decrease clearance.
As for Vd, it depends on how exactly renal function has been impacted. If there is significant fluid retention without affecting drug excretion then Vd would increased as plasma drug concentration would decrease. If both fluid and the drug is retained equally, then Vd may remain constant. If only drug excretion is affected or more affected, then Vd may decrease.