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How many stereoisomers for meso compound?

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ssodamy

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Please let me know. How do you calculate the stereoisomers for meso compound?

If there is 4 chiral centers and mirror image(symmetry line)on the compound, is the # of stereoisomer 4^2 - 1 or 4^2/2 ?
 

DAT12

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Usually minus 1 but I'm sure there can be exceptions where possibly minus 2 if multiple lines of symmetry
 
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