Definately more interesting, and your learning curve gets suddenly steeper as you take in tons of diseases in a very short amount of time (don't worry, if you review the physiology/biochem/etc. as you study the systems path, it helps immensely). Things definitely make more sense, and you find yourself "knowing" something as opposed to having to remember what that one medicine text or journal article said. You'll start seeing big-picture concepts. As Dr. Seusse said, "Oh the places you'll go!" You'll start learning physical exam better. You might find some doctors to start following and shadowing and have much more knowledge of what's going on and more ability to jump in and participate. You'll draw your first blood, you'll begin to get excited about doing medicine on rotations.
On the flip side, as you hit January you'll realize that you're downhill towards taking Step-1, and that's anxiety inducing for me right now. You'll realize you have that to study for as well as class, and you'll realize that all the little stuff in First Aid is definately superficial compared to what you really need to know for the test. You'll also realize that there's no real field of medicine concerned with Diagnostics, and surgery is not the most lifestyle friendly job if you want to pursue drama-filled relationships. Reading House of God may make you disillusioned too early. You'll start to learn that some classmates have started taking antidepressants, are dropping out, holding themselves back a year, etc. You'll wonder if you have a psych disease (as opposed to a terminal illness, the problem in first year). You'll start to feel as though the only thing you know is medicine and that your world consists of learning medicine and the people you see in medicine. That's a good cue to take an afternoon off and go somewhere downtown away from school without a medical book. Remember what it's like to be a human being.
DoctorP82, that is exactly what second year is like. I couldn't have said it better myself.
Right now I am excited to be almost done with classroom work, and excited about actually being on the wards next year, but at the same time I am not looking forward to step 1 at all!